Susceptibility to Biopsy-Proven Giant Cell Arteritis
نویسندگان
چکیده
Emma Dunstan, Sue Lester, Rachel Black, Maureen Rischmueller, Helen Chan, Alex W. Hewitt, and Catherine L. Hill 1 Rheumatology Department, 6e Queen Elizabeth Hospital, Woodville South, SA 5011, Australia 6e Health Observatory, Discipline of Medicine, 6e University of Adelaide, Adelaide, SA 5005, Australia Discipline of Medicine, 6e University of Adelaide, Adelaide, SA 5005, Australia Centre for Eye Research, Royal Victorian Eye and Ear Hospital, University of Melbourne, East Melbourne, VIC 3002, Australia 5 Lions Institute, University of Western Australia, Nedlands, WA 6009, Australia
منابع مشابه
Histopathologic Features of Giant Cell Arteritis in an Actinic Granuloma Lesion
The association between actinic granuloma and giant cell arteritis (temporal arteritis) has been claimed by some authors. There is a hypothesis that actinic radiation has the principal role in the etiology of both diseases in a similar way. Here, we report a case of actinic granuloma that had characteristic pathologic features of giant cell arteritis in histopathologic examination without clini...
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Giant cell arteritis is a systemic granulomatous vasculitis affecting medium to large arteries. An arteritic anterior ischemic optic neuropathy is the most common cause of permanent visual loss. Giant cell arteritis is very rare among Asians. We report six patients with biopsy-proven arteritic anterior ischemic optic neuropathy. Demographic data, clinical manifestations, laboratory findings, tr...
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OBJECTIVES Inflammatory cytokines are implicated in the pathogenesis of giant cell arteritis (GCA) and polymyalgia rheumatica (PMR). In this study we have examined the potential association of a CA repeat polymorphism in the first intron of the interferon gamma (IFN-gamma) gene with disease susceptibility and clinical expression of these conditions. METHODS Seventy-nine patients with isolated...
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OBJECTIVE Interferon (IFN) regulatory factors (IRF) are transcriptional mediators of IFN-induced signaling pathways and are involved in immune response. We have analyzed for the first time the association of 2 IRF5 gene variants in the susceptibility to giant cell arteritis (GCA). METHODS Two hundred twenty patients with biopsy-proven GCA and 520 matched controls were assessed. DNA from patie...
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OBJECTIVE Results of previous studies investigating the association between GCA and malignancy are conflicting. We performed a study of the risk of cancer in patients with biopsy-proven GCA. METHODS Patients with biopsy-proven GCA were identified from pathology reports of temporal artery biopsies from the major pathology laboratories in South Australia (SA). All subjects with biopsy-proven GC...
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